 |
 
|
 |
 |
| |
 |
|
|
| ||||||||||
|
|
|
|
|
|
|
||||
| ||||||||||
 |
|
|
|
Persons using assistive technology might not be able to fully access information in this file. For assistance, please send e-mail to: [email protected]. Type 508 Accommodation and the title of the report in the subject line of e-mail. Prevention of Perinatal Hepatitis B Through Enhanced Case Management -- Connecticut, 1994-95, and United States, 1994Each year, an estimated 20,000 infants are born to women in the United States who are positive for hepatitis B surface antigen (HBsAg). These infants are at high risk for perinatal hepatitis B virus (HBV) infection and for chronic liver disease as adults. To identify newborns who require immunoprophylaxis to prevent perinatal HBV infection (1-4), all vaccine advisory groups have recommended routine HBsAg screening of all pregnant women during an early prenatal visit in each pregnancy. Federal funding to support perinatal hepatitis B-prevention programs became available in 1990, and by 1992, programs had been implemented in all 50 states and the District of Columbia. Specific objectives of these programs are to ensure that 1) all pregnant women are tested for HBsAg, and 2) infants born to HBsAg-positive women receive hepatitis B immune globulin (HBIG) and hepatitis B vaccine at birth, with follow-up doses of vaccine at ages 1 and 6 months (5). This report describes the case-management features of successful hepatitis B-prevention programs in Connecticut during 1994-95 and in the United States during 1994. Connecticut In 1992, the Connecticut Department of Public Health implemented a perinatal hepatitis B-prevention program and recommended that 1) HBsAg-positive women be contacted before delivery and educated about HBV infection, 2) the infant's pediatrician and delivery hospital be informed of the mother's HBsAg status, and 3) a tracking system be used to ensure the infant receives appropriate postexposure prophylaxis. Local health departments (LHDs) initially were responsible for providing management to mother/infant pairs. Enhanced case management (ECM) was implemented in two counties in July 1994 and a third county in April 1995. In addition to use of the basic recommendations, the ECM program employed a full-time nurse (hired by the state) who worked on a flexible schedule to manage all mother/infant pairs in the three-county area and a computer-based tracking system to identify pending births to infected mothers and the need for follow-up vaccine doses for infants. To evaluate program effectiveness, outcomes in the ECM program were compared with the LHD programs for HBsAg-positive women identified during 1994-95. During 1994-95, the ECM program identified 64 HBsAg-positive pregnant women and maintained contact with all of these women throughout their pregnancies. During this period, LHD programs identified 71 HBsAg-positive pregnant women and established and/or maintained contact with 58 (82%). The mothers in the LHD programs resided in 27 different local health jurisdictions. Three of these jurisdictions managed greater than or equal to 10 mothers, and 18 each managed one. Documented compliance with the recommendation to administer HBIG and the first dose of hepatitis B vaccine within 24 hours of birth was higher in the ECM group (100%) than in the LHD group (90%) (Table 1). In addition, the rate of completion of the three-dose series by 6-8 months after birth was higher in the ECM program (91%) than the LHD programs (48%). No infants were lost to follow-up in the ECM program; in comparison, seven (12%) infants in the LHD programs were lost to follow-up without documentation that the series was completed. United States In March 1996, CDC conducted a survey to assess the effectiveness of the 58 federally funded perinatal hepatitis B-prevention programs for infants born to HBsAg-positive women in the United States during 1994. Of 8252 infants born to HBsAg-positive women, 7362 (89%) received HBIG and the first dose of hepatitis B vaccine at birth, and 5042 (61%) completed prophylaxis by age 6-8 months. As part of this survey, program coordinators completed a questionnaire about key programmatic elements; 48 (76%) of the 58 programs provided complete information. ECM techniques associated with an increased likelihood of vaccination of infants born to HBsAg-positive mothers (Table_1) included routine reminders to HBsAg-positive women that their status should be reported to the delivery hospital, reporting of the maternal HBsAg status on the newborn metabolic screening card or birth certificate, routine reminders to the prenatal-care providers that the mother's HBsAg status should be reported to the delivery hospital, and use of a computer-based tracking system for HBsAg-positive pregnant women and their infants. Reported by: AJ Roome, MPH, M Rak, JL Hadler, MD, State Epidemiologist, Connecticut Dept of Public Health. Epidemiology and Surveillance Div, National Immunization Program; Hepatitis Br, Div of Viral and Rickettsial Diseases, National Center for Infectious Diseases, CDC. Editorial NoteEditorial Note: Administration of appropriate immunoprophylaxis is approximately 90% effective in preventing perinatal HBV transmission (6). Because infants who are incompletely vaccinated with hepatitis B vaccine are at increased risk for perinatal HBV infection and less likely to be protected against infection compared with completely vaccinated children, timely provision of HBIG and the appropriate doses of vaccine is essential to prevention (7). The findings in this report indicate that, compared with all U.S. infants born to HBsAg-positive women, a substantially higher proportion of such infants in the ECM program in Connecticut received HBIG and were completely vaccinated with hepatitis B vaccine by age 6-8 months. One potential explanation for the increase in Connecticut was the use of comprehensive case-management techniques, including employment of staff specifically for the program, use of a computer-based tracking system, and use of reminder letters. Similar techniques improved case management in the national survey. In addition, reporting of maternal HBsAg status on newborn metabolic screening cards or birth certificates may help to ensure infants are vaccinated in the hospital and entered into tracking and recall systems at the state health department. Perinatal hepatitis B-prevention programs without intensive case management have been only moderately successful in ensuring that children of HBsAg-positive mothers are identified and complete the vaccine series by age 6-8 months. For example, in 1988, an evaluation of patients served by a large municipal hospital indicated that only 65% of infants at risk for perinatal HBV infection had received both HBIG and hepatitis B vaccine within 7 days after delivery (8). In addition, among 832 infants identified by a neonatal hepatitis B surveillance and vaccination program in New York City in 1988, only 59% had received HBIG and completed the vaccine series by age 18 months (9). Although this report did not include cost analysis, previous studies associate substantial cost savings with prevention of perinatal HBV transmission (10). For example, the estimated lifetime medical costs for one patient with cirrhosis of the liver (without transplantation) is $87,000; however, the costs associated with the techniques employed by the ECM program were not estimated. In addition, the integration of perinatal HBV-prevention programs with existing and new perinatal screening programs (e.g., maternal screening for human immunodeficiency virus and group B streptococcal infections) may improve overall cost effectiveness of these programs and facilitate comprehensive case management for other diseases that affect newborns. A national health objective for the year 2000 is to reduce by approximately 80% the number of perinatal HBV infections in the United States (objective 20.3). Based on the national survey described in this report, only half of all births to HBsAg-positive mothers in the United States are reported to a perinatal hepatitis B-prevention program and entered into a tracking system. Based on recent studies, widespread use of comprehensive case-management techniques similar to those used by newborn metabolic screening programs are needed to achieve the year 2000 objective. References
Table_1 Note: To print large tables and graphs users may have to change their printer settings to landscape and use a small font size.
TABLE 1. Number and percentage of infants who were born to HBsAg * -positive women and received hepatitis B immune
globulin (HBIG) and the vaccine series for hepatitis B, by program and characteristics -- Connecticut, 1994-95, and United
States, 1994
====================================================================================================================================
Infants who received Infants who received third
No. infants HBIG and hepatitis B dose of hepatitis B vaccine
born to vaccine at birth 6-8 months after birth
HBsAg-positive ------------------------ ----------------------------
Program/Characteristic women No. (%) p value No. (%) p value
---------------------------------------------------------------------------------------------------------
Connecticut
Use enhanced case-management
(ECM) techniques
Yes (ECM program) 64 64 (100) 0.01 + 58 (91) <0.01
No (local health department
program &) 58 52 ( 90) 28 (48)
United States @
Provide reminders to HBsAg-
positive women to report their
status to delivery hospital
Yes 6717 5978 ( 89) 0.16 4500 (67) <0.01
No 949 835 ( 88) 522 (55)
Report maternal HBsAg
status on newborn metabolic
screening card or birth
certificate **
Yes 4995 4545 ( 91) <0.01 3347 (67)
No 2617 2224 ( 85) 1649 (63)
Provide reminders to prenatal-
care providers to report
mother's HBsAg status
to delivery hospital
Yes 6786 6107 ( 90) <0.01 4547 (67) <0.01
No 880 713 ( 81) 493 (56)
Have computerized system
to track HBsAg-positive
pregnant women and their
infants
Yes 6778 6168 ( 91) <0.01 4541 (67) <0.01
No 888 693 ( 78) 471 (53)
---------------------------------------------------------------------------------------------------------
* Hepatitis B surface antigen.
+ Fisher exact two-tailed test.
& Documented compliance with the recommendation to administer HBIG and hepatitis B vaccine was verified with a chart review.
@ Only 48 of the 58 programs in the United States reported complete data. Data from these programs were obtained from both active
and passive surveillance systems.
** Excludes data for 54 infants for whom data were unknown.
====================================================================================================================================
Return to top. Disclaimer All MMWR HTML versions of articles are electronic conversions from ASCII text into HTML. This conversion may have resulted in character translation or format errors in the HTML version. Users should not rely on this HTML document, but are referred to the electronic PDF version and/or the original MMWR paper copy for the official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices. **Questions or messages regarding errors in formatting should be addressed to [email protected].Page converted: 09/19/98 |
| |||||||
This page last reviewed 5/2/01
|
