Notes from the Field: Escherichia coli O157:H7 Gastroenteritis Associated with a State Fair — North Carolina, 2011

On October 24, 2011, the North Carolina Division of Public Health (NCDPH) was notified of four Shiga toxin–producing Escherichia coli (STEC) infections among persons who had attended the 2011 North Carolina State Fair, held October 13–23 in Raleigh. Approximately 1 million visitors had attended the fair.

NCDPH conducted a case-control study to identify the source of transmission. A case was defined as laboratory evidence of STEC, hemolytic uremic syndrome (HUS), or acute bloody diarrhea with no other identified etiology in a person who attended the fair 1–10 days before illness onset. Active case finding was performed by using a network of hospital-based public health epidemiologists.* Passive surveillance was enhanced through notifications to public health officials, health-care providers, laboratory directors, and the public. Control subjects were recruited by contacting 11,000 randomly selected advanced ticket purchasers by e-mail with a request to participate in the investigation. Three control subjects were matched to each case by age (<18 years or ≥18 years) and date of fair attendance. A stool specimen was requested of all case-patients for laboratory confirmation of E. coli. Pulsed-field gel electrophoresis (PFGE) patterns were compared with known strains in the national PulseNet database.† Case-patients' exposures to food, animals, and fair activities were assessed by using a scripted questionnaire administered to case-patients and control subjects.

Twenty-five cases were identified with case-patients' illness onsets during October 16–25; median age was 26 years (range: 1–77 years). Eight case-patients (32%) were hospitalized; four (16%) experienced HUS. Nineteen case-patients provided stool specimens, and 11 (44%) had laboratory confirmation of E. coli O157:H7 with matching PFGE patterns. This PFGE pattern is the eighth most common pattern in the PulseNet database and has been associated with previous foodborne outbreaks (CDC, unpublished data, 2011).

The only exposure associated with illness was having visited one of the permanent structures in which sheep, goats, and pigs were housed for livestock competitions (matched odds ratio: 5.6; 95% confidence interval: 1.6–19.2). Fair attendees were not intended to have physical contact with animals in the building; however, 25% of case-patients (three of 12) and 24% of control subjects (five of 21) who visited the building reported direct contact with animals.

A previous STEC outbreak linked to a petting zoo at the 2004 North Carolina State Fair resulted in 187 illnesses, 15 of which were complicated by HUS (1). The 2004 outbreak led to the passage of Aedin's Law in North Carolina, which created regulations for exhibitions housing animals intended for physical contact with the public.§ These regulations include requirements for permitting, education, and signage to inform the public of health and safety concerns, enhanced maintenance of animal facilities, transitional entrances and exits, and easily accessible hand-washing stations. The 2011 outbreak was associated with an animal exhibit not subject to Aedin's Law. Preventive measures such as educational signs and hand-washing facilities were in place, based on national guidelines compiled in the 2011 Compendium of Measures to Prevent Disease Associated with Animals in Public Settings (2). As a result of this outbreak, a multiagency task force is being created in North Carolina to evaluate the preventive measures that were in place during the 2011 state fair and to identify additional interventions that could be applied to prevent disease transmission in livestock exhibitions where physical contact with the public might occur.

Reported by

Denise Griffin, Debra Springer, Zack Moore, MD, Levi Njord, MSc, Rebecca Njord, MSc, David Sweat, MPH, Nicole Lee, MPH, Jean-Marie Maillard, MD, Megan Davies, MD, North Carolina Dept of Health and Human Svcs. Aaron Fleischauer, PhD, Jennifer MacFarquhar, MPH, Career Epidemiology Field Officer Program; Stephanie Griese, MD, EIS Officer, CDC. Corresponding contributor: Stephanie Griese, [email protected], 919-715-7397.

Acknowledgments

Sue Lynn Ledford, Edie Alfano-Sobsey, Ruth Lassiter, Dianne Fore, Wake County Health Dept; Karen Beck, North Carolina Dept of Agriculture and Consumer Svcs; Leslie Wolf, Samuel Merritt, Evelyn Foust, North Carolina Dept of Health and Human Svcs. Thai-An Nguyen, Casey Barton Behravesh, Steven Stroika, Office of Infectious Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC.

References

1. Goode B, O'Reilly C. Outbreak of Shiga toxin producing E. coli (STEC) infections associated with a petting zoo at the North Carolina State Fair—Raleigh, North Carolina. Raleigh, NC: North Carolina Department of Health and Human Services; 2005. Available at http://epi.publichealth.nc.gov/gcdc/ecoli/ecolireportfinal062905.pdf. Accessed December 21, 2011.
2. CDC, National Association of State Public Health Veterinarians, Inc. Compendium of measures to prevent disease associated with animals in public settings, 2011. MMWR 2011;60(No. RR-4).